Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline
JF Rolland, A De Luca, R Burdi, F Andreetta… - Neurobiology of …, 2006 - Elsevier
Cell-attached patch-clamp recordings on native striated myofibers from adult dystrophic mdx
mice revealed a higher occurrence and open probability compared to non-dystrophic wild-
type myofibers of a 30 pS voltage-insensitive Ca2+-permeable channel, inhibited by Gd3+,
streptomycin and ruthenium red. Myofibers from in vivo exercised animals had higher
channel occurrence and/or open probability. Insulin-like growth factor 1 (3.3 nM) induced
and/or enhanced channel activity, via PI3 kinase, in wild-type but not in mdx myofibers …
mice revealed a higher occurrence and open probability compared to non-dystrophic wild-
type myofibers of a 30 pS voltage-insensitive Ca2+-permeable channel, inhibited by Gd3+,
streptomycin and ruthenium red. Myofibers from in vivo exercised animals had higher
channel occurrence and/or open probability. Insulin-like growth factor 1 (3.3 nM) induced
and/or enhanced channel activity, via PI3 kinase, in wild-type but not in mdx myofibers …
以上显示的是最相近的搜索结果。 查看全部搜索结果